Zebrafish made to grow pre-hands instead of fins

PERHAPS the little fish embryo shown here is dancing a jig because it has just discovered that it has legs instead of fins. Fossils show that limbs evolved from fins, but a new study shows how it may have happened, live in the lab.

Fernando Casares of the Spanish National Research Council and his colleagues injected zebrafish with the hoxd13 gene from a mouse. The protein that the gene codes for controls the development of autopods, a precursor to hands, feet and paws.

Zebrafish naturally carry hoxd13 but produce less of the protein than tetrapods - all four-limbed vertebrates and birds - do. Casares and his colleagues hoped that by injecting extra copies of the gene into the zebrafish embryos, some of their cells would make more of the protein.

One full day later, all of those fish whose cells had taken up the gene began to develop autopods instead of fins. They carried on growing for four days but then died (Cell, DOI: 10.1016/j.devcel.2012.10.015).

"Of course, we haven't been able to grow hands," says Casares. He speculates that hundreds of millions of years ago, the ancestors of tetrapods began expressing more hoxd13 for some reason and that this could have allowed them to evolve autopods.

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US school shooter blasted his way in: governor

 

NEWTOWN, Connecticut: The gunman in the Connecticut school massacre that left 20 small children dead blasted his way through a locked glass door, climbed through and proceeded with his killing spree, the state governor said on Sunday.

"He shot his way into the school. The school was locked. He used a weapon to open up the glass, and then walked in," Governor Dan Malloy said on the ABC program "This Week."

The shooter, Adam Lanza, fired "a number of rounds," Malloy said.

Police had previously said Lanza forced his way into the school but it was not clear if he did it by shooting his way in.

"He discharged to make an opening and then went through it, went to the first classroom, as you know, went to the second classroom," the governor said.

He added that authorities believe that, while shooting in the second classroom, the gunman heard police and emergency crews rushing to the scene of the massacre, Sandy Hook Elementary School, and took his own life.

The overall death toll was 28: the 20 children aged 6 or 7, six adults at the school, Lanza himself and his mother Nancy, whom he shot at her home before heading to the school.

Malloy said the first call for help from the school came from someone who was wounded but survived, and that first responders were swift.

"But, you know, this -- this sick fellow, you know, clearly mentally ill, killed his mother, proceeded to go on and kill a great number of people," Malloy said.

- AFP/xq

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Sam's Club in unintentionally hilarious Twitter exchange

Membership has its privileges.

(Credit:
Screenshot by Chris Matyszczyk/CNET)

If your job is to man a large company's Twitter account, it can be troubling task. It feels like you've been married to your customers for a very long time. They complain. They whine. They occasionally call you names.

Still, it's best to read what they send to you before you emit a standard reply that has been agreed by marketing, HR and a team of several cold-faced lawyers.

I mention this because of a slightly amusing exchange that crossed my Twitter feed this week. In the left corner was Sam's Club. In the right, the no-doubt highly clubbable John Hendren.

More Technically Incorrect

Should you be unaware of Hendren's merits, he is very good at writing "stupid stuff." I suspect, therefore, that he had espied Sam's Club's standard response to Twittered complaints. It reads: "We apologize and strongly urge you to contact our Member Service Center at 888-746-7726."

This seems reasonable enough. However, you might find an additional layer of nuance when I give you the text of Hendren's complaint.

It was: "@SamsClub I believe I have contracted an STI after using a toilet immediately after one of your store's managers. Who do I call?"

Some will immediately deduce that the person operating Sam's Twitter account didn't bother to read Hendren's message too closely. Some will complain that surely Sam's woman or man must have noticed that Hendren's handle is @fart.

Perhaps one or two might even remember Hendren from last year, when he retweeted people's whiny, ungrateful Xmas gift tweets.

I prefer to imagine that the person knew exactly what they were doing, had always thought the idea of a Members' Service Center was a target for guffaws and thought: "This is the funniest thing that's going to happen to me this week."

And it probably was.

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Space Pictures This Week: Frosty Mars, Mini Nile, More

Photograph by Mike Theiss, National Geographic

The aurora borealis, also known as the northern lights, illuminates the Arctic sky in a recent picture by National Geographic photographer Mike Theiss.

A storm chaser by trade, Theiss is in the Arctic Circle on an expedition to photograph auroras, which result from collisions between charged particles released from the sun's atmosphere and gaseous particles in Earth's atmosphere.

After one particularly amazing show, he wrote on YouTube, "The lights were dancing, rolling, and twisting, and at times looked like they were close enough to touch!" (Watch his time-lapse video of the northern lights.)

Published December 14, 2012

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Zebrafish made to grow pre-hands instead of fins

PERHAPS the little fish embryo shown here is dancing a jig because it has just discovered that it has legs instead of fins. Fossils show that limbs evolved from fins, but a new study shows how it may have happened, live in the lab.

Fernando Casares of the Spanish National Research Council and his colleagues injected zebrafish with the hoxd13 gene from a mouse. The protein that the gene codes for controls the development of autopods, a precursor to hands, feet and paws.

Zebrafish naturally carry hoxd13 but produce less of the protein than tetrapods - all four-limbed vertebrates and birds - do. Casares and his colleagues hoped that by injecting extra copies of the gene into the zebrafish embryos, some of their cells would make more of the protein.

One full day later, all of those fish whose cells had taken up the gene began to develop autopods instead of fins. They carried on growing for four days but then died (Cell, DOI: 10.1016/j.devcel.2012.10.015).

"Of course, we haven't been able to grow hands," says Casares. He speculates that hundreds of millions of years ago, the ancestors of tetrapods began expressing more hoxd13 for some reason and that this could have allowed them to evolve autopods.

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.

If you are having a technical problem posting a comment, please contact technical support.

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Nelson Mandela successfully treated for gall stones

PRETORIA: South African anti-apartheid icon Nelson Mandela on Saturday underwent a successful procedure to remove gall stones, a week after he was admitted to hospital for a lung infection, the office of the president said.

"This morning, 15 December 2012, the former president underwent a procedure via endoscopy to have the gall stones removed," it said in a statement.

"The procedure was successful and Madiba is recovering," it added, using the clan name by which Mandela is affectionately known.

The 94-year-old is being treated at a private hospital in the capital Pretoria. Initial tests revealed that he was suffering from a recurring lung infection.

"The medical team decided to attend to a lung infection before determining when to attend to the gall stones", the statement from the presidency said.

He was previously hospitalised for an acute respiratory infection in January 2011, when he was kept for two nights.

Mandela has a long history of lung problems dating back decades to when he contracted tuberculosis while in prison.

- AFP/de

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Space Pictures This Week: Frosty Mars, Mini Nile, More

Photograph by Mike Theiss, National Geographic

The aurora borealis, also known as the northern lights, illuminates the Arctic sky in a recent picture by National Geographic photographer Mike Theiss.

A storm chaser by trade, Theiss is in the Arctic Circle on an expedition to photograph auroras, which result from collisions between charged particles released from the sun's atmosphere and gaseous particles in Earth's atmosphere.

After one particularly amazing show, he wrote on YouTube, "The lights were dancing, rolling, and twisting, and at times looked like they were close enough to touch!" (Watch his time-lapse video of the northern lights.)

Published December 14, 2012

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School Shooting: Officials Seek Details on Gunman

The FBI is in at least three states interviewing relatives and friends of the elementary school gunman who killed 20 children, seven adults and himself, trying to put together a better picture of the shooter and uncover any possible explanation for the massacre, ABC News has learned.

The authorities have fanned out to New Jersey, Connecticut and Massachusetts to interview relatives of Adam Lanza, 20, and his mother, who was one of Lanza's shooting victims.

CLICK HERE for full coverage of the tragedy at the elementary school.

The victims died Friday when Lanza invaded Sandy Hook Elementary School in Newtown, Conn., and sprayed staff and students with bullets, officials said. Lanza also was found dead in the school.

Lt. Paul Vance said 18 children died in the school and two more died later in a hospital.

Six adults also were slain, bringing the total to 26. Among them was the school's principal, Dawn Hochsprung, multiple sources told ABC News. Another adult victim was teacher Vicki Soto, her cousin confirmed.

In addition to the casualties at the school, Lanza's mother, Nancy Lanza, was killed in her home, federal and state sources told ABC News.

According to sources, Lanza shot his mother in the face, then left his house armed with at least two semi-automatic handguns, a Glock and a Sig Sauer, and a semi-automatic rifle. He was also wearing a bulletproof vest.

READ: Connecticut Shooter Adam Lanza: 'Obviously Not Well'

Newtown Teacher Kept 1st Graders Calm During Massacre Watch Video

Newtown School Shooting: What to Tell Your Kids Watch Video

Lanza then drove to the elementary school and continued his rampage, authorities said.

It appeared that Lanza died from what was believed to be a self-inflicted gunshot wound. The rifle was found in his car.

"Evil visited this community today," Gov. Dan Malloy said at a news conference Friday evening.

CLICK HERE for more photos from the scene.

In the early confusion surrounding the investigation, federal sources initially identified the suspect as Adam's older brother Ryan Lanza, 24. Identification belonging to Ryan Lanza was found at the shooting scene, federal sources told ABC News.

Ryan Lanza soon took to Facebook to say he was alive and not responsible for the shooting. He later was questioned by police.

During the rampage, first-grade teacher Kaitlin Roig, 29, locked her 14 students in a class bathroom and listened to "tons of shooting" until police came to help.

"It was horrific," Roig said. "I thought we were going to die."

She said that the terrified kids were saying, "I just want Christmas. ... I don't want to die. I just want to have Christmas."

A tearful President Obama said Friday that there was "not a parent in America who doesn't feel the overwhelming grief that I do."

The president had to pause to compose himself after saying these were "beautiful little kids between the ages of 5 and 10."

As he continued with his statement, Obama wiped away tears from each eye. He has ordered flags flown as half staff.

It is the second worst mass shooting in U.S. history, exceeded only by the Virginia Tech shooting in 2007 when 32 were killed before the shooter turned the gun on himself. The carnage in Connecticut exceeded the 1999 Columbine High School shooting in which 13 died and 24 were injured.

Friday's shooting came three days after masked gunman Jacob Roberts opened fire in a busy Oregon mall, killing two before turning the gun on himself.

The Connecticut shooting occurred at the Sandy Hook Elementary School, which includes 450 students in grades K-4. The town is located about 12 miles east of Danbury, Conn.

The massacre prompted the town of Newtown to lock down all its schools and draw SWAT teams to the school, authorities said.

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Satellite upgrade should let planes slash emissions

A CONSTELLATION of next-generation communications satellites has a surprise in store for the environment. When Iridium Communications begins launching replacement orbiters in 2015, it will do much more than upgrade its satphone services. Piggybacking on the satellites will be a set of transmitters that could revolutionise long-haul flight, save airlines billions of dollars worth of fuel and prevent millions of tonnes of carbon emissions.

For the first time, these devices, known as ADS-B transponders, will enable air traffic controllers to locate aircraft that are far out over oceans, remote deserts or the poles where there is no radar coverage. On top of the greater safety this offers airlines if a plane gets into trouble, say, it will also let controllers pack planes in closer together along optimal flight paths, which will cut carbon emissions.

The ADS-B radio transmitting system is designed to replace expensive, unreliable and low-range radar tracking. It bundles an aircraft's call sign, GPS position, speed and altitude into 112-bit digital packets, which are broadcast continually from the aircraft to the control stations.

But like today's radar, ADS-B radio packets have limited range. "If you're way out in the Pacific or over the North Pole no one's going to pick it up," says Dan Mercer of Iridium Communications. So the transponders piggybacking on the new satellites will pick up those signals and beam them back down to Earth. "For the first time, they'll have total vision of the aircraft at all times," Mercer says.

To avoid potential collisions, planes on long-haul routes out over the oceans currently have to fly quite a long way apart. And only some planes can fly in air lanes with kind tailwinds, while others have to push through less-favourable air currents. "If air traffic control can see where aircraft are precisely, they can fly them all closer together and on the most efficient routes. So they will save fuel and cut emissions," says Mercer.

A study commissioned by Iridium found that between the service's proposed start in 2017 and 2030, the technology should save airlines about $7 billion on fuel and cut carbon dioxide and nitrogen oxide emissions by 35 million tonnes. Another projection that looked at just North Atlantic flights says orbital ADS-B will save airlines $110 million in fuel and 300,000 tonnes in emissions in 2018 alone.

The system can "improve the efficiency of oceanic air traffic management by reducing aircraft separation distances and allowing greater route optimisation", says Pauline Lamb, operations director of National Air Traffic Services in Prestwick, UK. She adds that her organisation is working to fully understand the benefits it will provide.

Meanwhile, one of the world's largest air traffic management firms, Nav Canada of Ottawa, Ontario, has formed Aireon, a joint venture with Iridium. Aireon will operate and sell the transponder service to airlines and air traffic control providers. In combination with other measures - such as use of lighter carbon fibre planes and more efficient engines - Iridium's move should help aviation fight its environmental corner.

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.

If you are having a technical problem posting a comment, please contact technical support.

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MICE organisers reeling from rising rentals and wages

SINGAPORE : It is a mixed bag for Singapore's Meetings, Incentives, Conventions and Exhibitions (MICE) sector. Exhibition venues are raking in the cash, but event organisers have said they are reeling from rising rentals and wages.

Resorts World Sentosa (RWS) said attractions such as its Marine Life Park are luring in customers.

RWS will pull in 600,000 delegates for 3,000 events this year - 20 per cent more than last year. And it is convinced there is more upside.

Noel Hawkes, vice president of Attraction Sales at Resorts World Sentosa Singapore, said: "2013 is going to be an interesting year. The world economy is a bit shaky at the moment, but we are cautiously optimistic that we will continue to grow our business. And we can definitely see a growth of at least 10 per cent in our MICE business.

To keep up with competition, RWS said it must not "rest on its laurels" and has to continuously find new products to excite customers.

Visitors can expect a new "Sesame Street" ride to be unveiled at Universal Studios in the first quarter of next year.

In this business, the old adage "you have got to spend money to make money" rings true.

Suntec Singapore will close its doors for six months for wide-scale renovations, and it is convinced the facelift will give it an edge over the competition.

Arun Madhok, CEO of Suntec Singapore, said: "Our entire building is re-modelled to deliver a high level of flexibility. This will allow us to meet the volume needs of customers.

"We are improving our food production techniques and service style. We are adding a whole range of technology into the building to actually assist us in delivering the perfect experience for our customers."

But it isn't rosy for everyone.

Event organisers like Conference & Exhibition Management Services said they are in a fix.

Edward Liu, managing director of Conference & Exhibition Management Services, said: "Most of the venues that we make use of...tend to increase their rental rates every couple of years.

"Their rationale is that they are also facing cost challenges due to manpower costs, maintenance and so forth. So obviously, they are passing the higher charges to the hirers of their facilities."

Mr Liu added that event organisers now need to secure about 1,500 square metres of exhibition space, or about 150 booths in order to breakeven. That is an increase of 15 per cent in 10 years.

The organisers warn if they do not fill their event calendars, the rising cost of rentals and wages will squeeze their margins.

- CNA/ms

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