Grapefruit makes drugs pack a stronger punch

A healthy breakfast of half a grapefruit? Not advisable if you are taking certain prescription drugs – the interaction with the fruit could result in an inadvertent overdose.

To find out the extent of the effect, David Bailey of the University of Western Ontario in London, Canada, reviewed the literature and prescribing information of various drugs for any mention of a reaction. He found that of the 85 drugs known to interact with grapefruit, 43 can result in severe adverse effects. The number has increased by 24 per cent since 2008 because new drugs have come onto the market.

Chemicals in the fruit destroy an enzyme in the body that normally breaks down substances such as drugs. That means the drug keeps circulating in the body, which can lead to overdose. A glass of the juice is enough, even if drunk hours before taking a drug, says Bailey.

The most serious adverse effect is a condition known as torsade de pointes, which can cause cardiac arrest and death. It can occur if you mix grapefruit and anticancer drugs.

"Care should definitely be taken with certain drugs," says Bill Widmer of the US Horticultural Research Laboratory in Fort Piece, Florida, but he adds that there are people who "believe the problem is overstated".

Journal reference: Canadian Medical Association Journal, DOI: 10.1503/cmaj.120951

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Govt to offer steady supply of residential land in 2013: analysts

SINGAPORE: The government is expected to offer a steady supply of land for residential developments in the first half of 2013.

Property-watchers said the sites offered this year have seen strong interest from developers, pushing land prices up by an average of some 10 per cent on-year.

To meet demand, the government has ramped up its land sales programme this year.

For both the first and the second half of 2012, it offered sites which could yield more than 14,000 private homes.

Of those, about half were placed under the Confirmed List, and the remaining under the Reserve List.

Analysts said the demand has been strong, with an average of 6 to 8 bids per site for land plots costing above S$200 million.

New land supply is expected to be on tap in the first six months of 2013 as well.

Nicholas Mak, executive director of SLP International Property, said: "The government is likely to offer about the same number of development sites on the Confirmed List with about another 12 to 15 other development sites on the Reserve List.

"The number of private homes that can be potentially be developed on these Confirmed List sites will probably be 6,500 to 7,500."

Under the Reserve List system, a site will only be put up for tender if the developer's minimum bid price is acceptable to the government.

Analysts said there will likely be sites for more executive condominiums, private homes and mixed developments.

Some of these sites could be in Woodlands, Jurong Lakeside and the north-eastern part of the island.

Chua Yang Liang, head of research at Jones Lang LaSalle, said: "Your Punggol, Sengkang belt coming down downtown, that area is likely to see significant proportion of overall sales, and the state will continue to use the sale programme to drive urbanisation in these areas."

Some analysts said the price gap between land prices under the government land sales programme and collective sales has narrowed somewhat this year and it could spur more activity in the enbloc sales market in 2013.

Donald Han, special advisor at HSR, said: "The pace of price increase that we saw, about 10 to 15 percent in the last 12 months for just government land sales of sites.

"That narrowing factor would moved some developers from GLS market to look at collective sale market.

"(Developers could look into the collective en bloc sale) as a purpose of land banking, rather than the GLS (which is) more for immediate turnaround, and sell into the market place)."

Analysts expect prices for government land to continue to increase, but at a slower pace next year.

- CNA/lp

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iPhone 5 helps iOS retake smartphone market from Android in Q3

The
iPhone 5 has proved to be a major factor in
Android's battle with Apple's iOS.

According to new data published today by research firm Kantar Worldpanel ComTech, iOS was able to nab 48.1 percent of the U.S. smartphone market during the 12-week period ended October 28, just beating out Android's 46.7 percent share.

However, elsewhere around the world, iOS isn't nearly as popular. According to the research firm, Android was running on 73.9 percent of all smartphones purchased in Germany during the same period. Android took 81.7 percent of Spain's smartphone market.

Apple's success during the 12-week period came byway of the iPhone 5, Kantar said. The company noted that the last time iOS led Android in its studies was when the
iPhone 4S hit store shelves last year. iOS held on to the top spot for three consecutive periods before eventually giving ground to Android.

Apple launched the iPhone 5 in late-September, giving it only one month to affect the Kantar survey. Kantar didn't say how many iPhone 5 units Apple sold during the period, but the company noted that 62 percent of iPhone 5 buyers in the U.S. already owned an iPhone. The research firm found that 13 percent of Android owners switched to the iPhone, compared to 6 percent of BlackBerry device owners.

Apple has benefited most from customer loyalty. According to Kantar, 92 percent of those who own an iPhone will upgrade to another Apple smartphone when they can.

Kantar's study comes just a few weeks after research firm IDC offered up its own evaluation of the smartphone market during the third quarter. That company found that Android owned 75 percent of the worldwide smartphone market, leaving just 14.9 percent to iOS.

(Via Patently Apple)

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Space Pictures This Week: Space "Horse," Mars Rover, More

• 
  
  
  
  
  
  
  

  High Horse

  Photograph by Greg Parker, Your Shot
  

  The Horsehead Nebula rears its pretty head in a November 17 photograph submitted to National Geographic's Your Shot photo community.

  Taken from the New Forest Observatory in the United Kingdom, the image shows how the nebula's horse head is part of a larger cloud of dust. Situated about 1,500 light-years away, the Horsehead Nebula is visible only because its obscuring dust is silhouetted against another, brighter nebula, according to NASA.

  (See "'Soccer Ball' Nebula Discovered by Amateur Astronomer.")

  Published November 26, 2012

  
  











• 
  
  
  
  
  
  
  
  











• 
  
  
  
  
  
  
  

  Green Lit

  Photograph by Jeremy La Zelle, My Shot
  

  Green curtains of aurora stretch over the sky in the Alaska Arctic in a picture submitted to National Geographic's My Shot on November 17.

  "The constantly changing kaleidoscope of colors are reminiscent of a fireworks display—but without sound," photographer Jeremy La Zelle wrote with his submission.

  "All we hear is the quiet peaceful sounds of a freezing Alaska night."

  (See "Aurora Pictures: Best Fall Photos of Northern Lights.")

  Published November 26, 2012

  
  











• 
  
  
  
  
  
  
  

  Martian Vista

  Image courtesy Caltech/NASA
  

  NASA's Curiosity rover snapped this picture after moving 83 feet (25 meters) eastward on November 18—the 102nd Martian day, or sol, of its mission to study whether life once existed on Mars.

  The view shows Yellowknife Bay, part of the Glenelg area of the Gale Crater, which is located near the base of a three-mile-high (five-kilometer-high) mountain rich with layered sediment deposits laid down over hundreds of millions of years.

  (Read more about the Gale Crater.)

  Published November 26, 2012

  
  











• 
  
  
  
  
  
  
  

  Gilded Mountains

  Image courtesy ESA

  The sands of the Sahara appear like golden brush strokes around the Tibesti Mountains in a March 2012 satellite image recently released by the European Space Agency.

  Located in Chad and Libya, the mountains' highest peak is Emi Koussi-pictured above as a circular structure in the lower-right portion of the dark area.

  Lava flows can be seen extending from the westernmost volcano, Toussidé.

  (See volcano pictures.)

  Published November 26, 2012

  
  











• 
  
  
  
  
  
  
  

  Photograph by Quang Nguyen Luong and F. Motte, Herschel SPIRE/ESA

  Published November 26, 2012

  
  

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Record Powerball Jackpot to Grow Even Bigger

The jackpot for Wednesday's Powerball drawing now stands at $425 million -- the richest Powerball pot ever -- and it's likely to get even sweeter.

"Back in January, we moved Powerball from being a $1 game to $2," says Mary Neubauer, a spokeswoman for the Iowa lottery. "We thought at the time that this would mean bigger and faster-growing jackpots."

It's proved true. The total, she says, "has been taking huge jumps -- another $100 million since Saturday." (The most recent drawing, on Saturday night, produced no winning numbers.)

Until now, the biggest Powerball pot on record -- $365 million -- was won in 2006 by eight Lincoln, Neb., co-workers.

In Photos: Biggest Lotto Jackpot Winners

Lottery officials in Iowa, where Powerball is headquartered, have started getting phone calls from all around the world. "When it gets this big," says Neubauer, "we start getting inquiries from Canada and Europe from people wanting to know if they can buy a ticket. They ask if they can FedEx us the money."

Don Smith/The Record (Bergen County)/AP Photo

Powerball Drawing No Winner; Jackpot Grows to $425 Million Watch Video

Powerball Fever: Millions Chase the Chance to Hit Jackpot Watch Video

The answer she has to give them, she says, is: "Sorry, no. You have to buy a ticket in a member state from a licensed retail location."

About 80 percent of players don't choose their own Powerball number, opting instead for a computer-generated one.

Asked if there's anything players can do to improve their odds of winning, Neubauer says no -- apart from buying a ticket, of course.

Lottery officials put the odds of winning Wednesday's Powerball pot at one in 175 million, meaning you are 25 times more likely to win an Academy Award.

Skip Garibaldi, a professor of mathematics at Emory University in Atlanta, provides additional perspective: You are three times more likely to die from a falling coconut, he says; seven times more likely to die from fireworks, "and way more likely to die from flesh-eating bacteria" (115 fatalities a year) than you are to win the Powerball lottery.

Segueing, then, from death to life, Garibaldi notes that even the best physicians, equipped with the most up-to-date equipment, can't predict the timing of a child's birth with much accuracy.

"But let's suppose, however, that your doctor managed to predict the day, the hour, the minute and the second your baby would be born," Garibaldi says. The doctor's uncanny prediction would be "at least 100 times" more likely than your winning Wednesday.

Even though he knows the odds all too well, Garibaldi says he'll usually play the lottery. "When it gets this big, I'll buy a couple of tickets. It's kind of exciting. You get this feeling of anticipation. You get to think about the fantasy."

So will he be purchasing two tickets for Wednesday's Powerball? "I can't," he tells ABC News. "I'm in California" -- one of eight states that doesn't offer Powerball.

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Water-hating shoes repel (almost) any liquid

Joanna Carver, reporter

If you wear white sneakers outside, chances are they won't stay clean for long. But thanks to a new superhydrophobic coating that is claimed to completely repel water and heavy oils, your shoes should look like new for longer - and keep your feet dry at the same time.

Developed by Ross Nanotechnology of Lancaster, Pennsylvania, the spray, called NeverWet, allows liquids to roll off without touching the underlying surface. Company president Andy Jones declined to reveal any trade secrets but he does say that the silicon-based aerosol is made of nanoparticles that self-assemble when sprayed. 

The company sent us a pair of trainers with one shoe treated with the spray, so we decided to test them out on the streets of London. In this video, you can see red wine skip off the surface while viscous sauces like ketchup and caramel roll off without leaving a trace. But NeverWet can't resist everything: it's vulnerable to most solvents, for example acetone or ethanol. By subjecting the shoe to a dose of spray paint, we manage to ruin its nearly pristine exterior.

The aerosol can also be applied to electronics: a dramatic video reveals how an iPhone coated with the substance remains fully functional when submerged in a bowl of water for 30 minutes.
NeverWet is set to go on sale in the US before the end of the year, and internationally soon after.

For more on ultra-repellant materials, check out our full-length feature "Omniphobia: the stuffs that stick at nothing"
or watch a super-slippery material, inspired by a carnivorous plant, in action.

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More public companies in the Philippines eyeing Singapore market for funds

SINGAPORE: More Filipino companies may be looking at the Singapore market to raise funds, with some eyeing a dual listing while others an initial public offering (IPO), say analysts.

Public companies in the Philippines that seek to list on the Singapore Exchange (SGX) usually do so to raise their profile and broaden their investor base.

Filipino food producer Alliance Select Foods International is seeking to list on Singapore's SGX-Catalist board in 2013, a move that will make it the first publicly-traded Filipino company to debut in Singapore.

Alliance Select Foods International was incorporated in 2003 and listed on the Philippines Stock Exchange in 2006, with Singapore investors forming its largest shareholders.

"Singapore is a regional hub for finance especially in ASEAN. We felt very strongly because of our strong Singapore based shareholders, we felt that it was natural for us to seek a dual listing here in Singapore," said Jonathan Dee, president and CEO of Alliance Select Foods International

"The interest rate in Singapore is (also) much lower than that of the Philippines… we chose the Catalist primarily because of our size. Our market cap today is 50 million dollars and so Catalist would fit perfectly with that," he added.

Experts also said that it was time for local investors to start looking at investment opportunities in the Philippine stock exchange, as the Filipino market gains attention in the international arena.

The Philippines' stock market is Asia's 12th largest with a market capitalisation of about US$212 billion.

"There are international investors, especially banks, which are actually overweight in the Philippines in terms of their Asia exposure, primarily because they see Philippines as a re-flation story," said Daryl Liew, head of Portfolio Management at Reyl.

"It's pretty much a domestic consumption play which is a pretty hot theme at this point in time. And actually if you look at the stock market performance, the Philippines stock market is probably the best stock market performance year to date," said Mr Liew.

"Last I checked it's up about 27 per cent, which is higher than the Thai stock market, the Indian stock market and the Hang Seng," he added.

Some public companies in the Philippines are already popular with international institutional investors.

Once the Philippines stock exchange is connected with the ASEAN trading link, analysts say these new linkages will help elevate its profile as well as increase retail investors' interest in Filipino public companies.

The ASEAN trading link comprises seven exchanges in six countries, with the Singapore Exchange and Bursa Malaysia being the first two exchanges to connect in September 2012. The stock exchange of Thailand followed suit on 15th October.

- CNA/jc

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Canon PowerShot SX150 IS megazoom drops below $100

If you've got someone on your shopping list who wants to learn more about controlling camera shutter speeds and apertures, Canon's PowerShot SX150 IS is a good and inexpensive option. Even more so now that Target has dropped its price to $99.99.

The 14-megapixel camera features a 12x, f3.4-5.6, 28-336mm lens with optical image stabilization, a 3-inch LCD, and full manual to full auto shooting modes. It's also powered by AA-size batteries, so it's a good choice for travelers, too, who don't want to worry about easy battery replacement.

The shooting performance is a bit slow, though, but if you're trying to learn more about changing settings to get your desired results, that's not necessarily a bad thing.

However, if speed is a problem, its successor, the SX160 IS, promises better autofocus performance that considerably speeds up shooting. It also has a longer zoom lens: 16x, f3.5-5.9, 28-448mm.

And despite being only a couple months old, it's selling for $80 less than its MSRP at $149.99 from many stores.

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Distant Dwarf Planet Secrets Revealed

Orbiting at the frozen edges of our solar system, the mysterious dwarf planet Makemake is finally coming out of the shadows as astronomers get their best view yet of Pluto's little sibling.

Discovered in 2005, Makemake—pronounced MAH-keh MAH-keh after a Polynesian creation god—is one of five Pluto-like objects that prompted a redefining of the term "planet" and the creation of a new group of dwarf planets in 2006. (Related: "Pluto Not a Planet, Astronomers Rule.")

Just like the slightly larger Pluto, this icy world circles our sun beyond Neptune. Researchers expected Makemake to also have a global atmosphere—but new evidence reveals that isn't the case.

Staring at a Star

An international team of astronomers was able for the first time to probe Makemake's physical characteristics using the European Southern Observatory's three most powerful telescopes in Chile. The researchers observed the change in light given off by a distant star as the dwarf planet passed in front of it. (Learn how scientists found Makemake.)

"These events are extremely difficult to predict and observe, but they are the only means of obtaining accurate knowledge of important properties of dwarf planets," said Jose Luis Ortiz, lead author of this new study and an astronomer at the Instituto de Astrofisica de Andalucia, in Spain.

It's like trying to study a coin from a distance of 30 miles (48 kilometers) or more, Ortiz added.

Ortiz and his team knew Makemake didn't have an atmosphere when light from the background star abruptly dimmed and brightened as the chilly world drifted across its face.

"The light went off very abruptly from all the sites we observed the event so this means this world cannot have a substantial and global atmosphere like that of its sibling Pluto," Ortiz said.

If Makemake had an atmosphere, light from the star would gradually decrease and increase as the dwarf planet passed in front.

Coming Into Focus

The team's new observations add much more detail to our view of Makemake—not only limiting the possibility of an atmosphere but also determining the planet's size and surface more accurately.

"We think Makemake is a sphere flattened slightly at both poles and mostly covered with very white ices—mainly of methane," said Ortiz.

"But there are also indications for some organic material at least at some places; this material is usually very red and we think in a small percentage of the surface, the terrain is quite dark," he added.

Why Makemake lacks a global atmosphere remains a big mystery, but Ortiz does have a theory. Pluto is covered in nitrogen ice. When the sun heats this volatile material, it turns straight into a gas, creating Pluto's atmosphere.

Makemake lacks nitrogen ice on its surface, so there is nothing for the sun to heat into a gas to provide an atmosphere.

The dwarf planet has less mass, and a weaker gravitational field, than Pluto, said Ortiz. This means that over eons of time, Makemake may not have been able to hang on to its nitrogen.

Methane ice will also transform into a gas when heated. But since the dwarf planet is nearly at its furthest distance from the sun, Ortiz believes that Makemake's surface methane is still frozen. (Learn about orbital planes.)

And even if the methane were to transform into a gas, any resulting atmosphere would cover, at most, only ten percent of the planet, said Ortiz.

The new results are detailed today in the journal Nature.

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President Obama Prepares for Cabinet Shuffle

Nov 26, 2012 6:45am

Carolyn Kaster/AP Photo

As President Obama prepares for his second term, preparations have begun for the traditional shuffling of the Cabinet.

Top priority for the president: filling slots for those top officials heading — if not running — for the door: Secretary of State Hillary Clinton and Secretary of the Treasury Tim Geithner.

To replace Clinton, Democratic insiders suggest that U.S. Ambassador to the United Nations Dr. Susan Rice is the frontrunner, with Sen. John Kerry, D-Mass., also a viable candidate.

Rice has been harshly criticized by Republicans for the erroneous comments she made on Sunday news talk shows after the attack on the U.S. compound in Benghazi, Libya, comments that were based on intelligence reports that falsely blamed the attack on a protest against an anti-Muslim video. When the president, during his recent press conference, offered a vociferous defense of Rice, many of those close to him began to suspect he was tipping his hand as to what he might decide.

To replace Geithner at Treasury, White House chief of staff Jack Lew is thought to have the inside track if he wants it, with other possibilities including Neal Wolin, the current deputy secretary of the Treasury and Lael Brainard, current under secretary of the Treasury for international affairs.

Other informed sources suggest that there is consideration being given to a business/CEO type such as investor Roger Altman, former Time/Warner chair Richard Parsons, and Facebook’s Sheryl Sandberg.

Those are the two most pressing jobs to fill, with Clinton exhausted from a long stretch in government — eight years as first lady, eight as senator, and four as secretary of state — and the president having personally promised Geithner’s wife that he could leave as soon as possible after the election.

Any of the business/CEO types being discussed for treasury secretary could also serve as secretary of commerce, a position that for the Obama administration has proved as troublesome as the role of drummer in Spinal Tap. Jeff Zients, the acting director of the Office of Management & Budget, is said to be under consideration.

It’s too flip to refer to it as a consolation prize, but informed sources say that — with Defense Secretary Leon Panetta also planning on leaving — Kerry could be offered the position secretary of defense if he wants it, though the Massachusetts senator has suggested he only wants State. Another option, Michelle Flournoy, a former under secretary of defense for Policy, would be the first female to serve in that position. There was some discussion of National Security Adviser Tom Donilon moving across the river, but it seems clear, sources say, that he’s staying where he is.

If Lew leaves to take the position at Treasury, some possible replacements for him as chief of staff include deputy National Security Adviser Denis McDonough or Vice President Biden’s former chief of staff Ron Klain. Tom Nides, deputy secretary of state for management and resources, has also been discussed.

President Obama’s senior adviser David Plouffe has also long discussed leaving the White House. There are many options to fill his shoes, including the elevation of communications director Dan Pfeiffer. Also possible: bringing back former press secretary Robert Gibbs, or former deputy chief of staff/campaign manager Jim Messina. Another option might be to bring in some of the people who were part of the messaging shop in the campaign — David Simus, who served as director of opinion research for the campaign, or Larry Grisolano, who did ads for campaign.

– Jake Tapper

SHOWS: World News

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